genosmart DX EGFR Hotspots ^PlasmaDNA

Circulating tumor DNA testing for EGFR hotspots

Useful for

The DB-DNA-EGFR-Plasma Focus is a targeted resequencing assay for the analysis of hotspots in the EGFR gene with known relevance to lung cancer therapies. The assay is circulating tumour DNA-based and identifies variations from the plasma.

Speciment type requirements

2x ~10 ml of blood in PAX or Streck tubes

Required information

Known variants in the tumour sample

Clinical interpretation

Targeted cancer therapies are defined as antibody or small molecule drugs that block the growth and spread of cancer by interfering with specific cell molecules involved in tumour growth and progression. Multiple targeted therapies have been approved for treatment of specific cancers. Molecular genetic profiling is often needed to identify targets amenable to targeted therapies and to minimize treatment costs and therapy-associated risks.

Cautions

This test cannot differentiate between somatic and germline alterations. Additional testing may be necessary to clarify the significance of results if there is a potential hereditary risk. DNA variants of uncertain significance may be identified. A negative (wild-type) result does not rule out the presence of a mutation or rearrangement (fusion) that may be present but below the limits of detection of this assay. Rare polymorphisms may be present that could lead to false-negative or false-positive results. Test results should be interpreted in the context of clinical findings, tumour sampling, and other laboratory data. If results obtained do not match other clinical or laboratory findings, please contact the laboratory for updated interpretation. Misinterpretation of results may occur if the information provided is inaccurate or incomplete.